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Cost of bupropion in australia, a comparison with naltrexone for alcohol addiction and an analysis of differences in bupropion side effects, side-effect profiles and burden between bupropion SR from i-pill and ER continuous-release (CR) format. METHOD: We did a systematic review of all randomised trials bupropion SR for the treatment of opioid addiction, assessed the safety, tolerability and efficacy of bupropion SR (in all dose and oral delivery forms), conducted a meta-analysis of bupropion SR and antidepressant, antipsychotic, or stimulant therapy by excluding studies that excluded at least one medication used for the treatment of opioid addiction. RESULTS: Fifty-five studies were identified, of which 23 studies compared bupropion DR (i.e. active-placebo) with SR (in one daily dose form), 2 studies compared bupropion ER (CR) with SR, and 14 studies compared bupropion ER with naltrexone (TR). All comparisons were between SR and SR; no trials compared SR with antidepressant, antipsychotic, or stimulant therapy. Of the 23 studies comparing bupropion SR with ED, 19 (58%) compared them as active-placebo, 5 (18%) compared SR with an antidepressant or antipsychotic medication, 1 (5%) compared bupropion SR is an antipsychotic medication, and 0, 1 0 studies compared bupropion SR with an antidepressant medication. When bupropion SR and ER were compared with naltrexone, 2 trials were included. Overall, there was no statistically significant heterogeneity in clinical response rate (OR 0.82 [95% CI 0.65-1.00]), Fgr 100 generic viagra serious adverse events (OR 2.23 [CI 1.25-4.67]), bupropion side effect profile (OR 1.31 [CI 0.79-2.12]), bupropion side-effect burden (OR 1.00 [CI 0.78-1.23]), or patient-reported side-effects (OR 0.65 [CI 0.43-0.91]). CONCLUSION: Given the lack of evidence differences in adverse effect profile across bupropion ER from continuous-release (CR) and SR, the ongoing promotion of bupropion ER as a standard opioid agent for drug-abuse treatment likely has limited utility, with adverse side-effects more prominent in the treatment of opioid addiction than in acute, acute-phase detoxification. Bupropion SR is a safer and well-tolerated treatment than bupropion ER for opioid addiction. "What about the rest of world?" It's something I hear a lot from my friends and colleagues when discussing globalization, about trade. Often, it comes up in a discussion about "the new economy" or how our world is changing — a question that often arises when economists offer the views of great ones. For example, think of the old saying that any new technology requires industries and a massive supply of jobs. That's what happened, after all, with computerization, and it would be equally true with globalization. But globalization isn't inevitable. Consider the most recent wave of trade liberalization that began a few years ago. What will come of the millions jobs it created? In the case of Mexico, they were not just lost in the countryside; factories that were a part of the massive wave job creation were closed down in a few years. For the rest of hemisphere, it has created a lot of high-paying jobs — but they were not in manufacturing, because most of the new jobs were in service sectors — such as catering, food service, retail, banking.